NUPACK: Analysis and design of nucleic acid systems

نویسندگان

  • Joseph N. Zadeh
  • Conrad Steenberg
  • Justin S. Bois
  • Brian R. Wolfe
  • Marshall B. Pierce
  • Asif R. Khan
  • Robert M. Dirks
  • Niles A. Pierce
چکیده

UNLABELLED The Nucleic Acid Package (NUPACK) is a growing software suite for the analysis and design of nucleic acid systems. The NUPACK web server (http://www.nupack.org) currently enables: ANALYSIS thermodynamic analysis of dilute solutions of interacting nucleic acid strands. DESIGN sequence design for complexes of nucleic acid strands intended to adopt a target secondary structure at equilibrium.Utilities: evaluation, display, and annotation of equilibrium properties of a complex of nucleic acid strands. NUPACK algorithms are formulated in terms of nucleic acid secondary structure. In most cases, pseudoknots are excluded from the structural ensemble.

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عنوان ژورنال:
  • Journal of computational chemistry

دوره 32 1  شماره 

صفحات  -

تاریخ انتشار 2011